Oxycodone vs Percocet: If you have a question about which is best for you then Oxycodone and percocet both are very powerful opioid medications, when it comes to comparing them then it depends upon your health condition. When you have short-term pain it’s managed by percocet while oxycodone is used for both short-term and chronic pain. Both medications are best according to your health condition and both medications have high risks for dependence and addiction so before taking this medication consult with your doctor.