Provigil (Modafinil): Precision Wakefulness Backed by MedicineProvigil is the brand-name formulation of modafinil, a prescription medication developed to improve wakefulness in people affected by excessive daytime sleepiness. It is commonly prescribed for narcolepsy, obstructive sleep apnea–related fatigue, and shift work sleep disorder. Unlike traditional stimulants, Provigil is known for promoting alertness without the crash, anxiety, or hyperstimulation often associated with amphetamines.